Antibody Response After First and Second BNT162b2 Vaccination to Predict the Need for Subsequent Injections in Nursing Home Residents
نویسندگان
چکیده
Objectives: A massive immunization program was initiated in France older adults. The aim of the study to assess antibody response following BNT162b2 vaccination nursing home (NH) residents. Methods: Three hundred and sixty-nine NH residents who received two vaccine doses were tested for three weeks after first dose six second dose. We assessed IgG level against SARS-CoV-2 Receptor-Binding Domain (RBD-IgG) nucleoprotein-IgG (SARS-CoV-2 II Quant Alinity assays, Abbott Diagnostics). Results: In with prior infection, high RBD-IgG levels (≥ 4,160 AU/mL) observed 99/129 (76.9%), no additional gain 74 (74.7%). However, a low RDB-IgG (<1,050 28 (21.7%) residents. persistence longer interval between infection associated higher (p<0.0001 p=0.0013, respectively). without below 50 AU/mL predicted failure reach significant concentration 1,050 (predictive positive value: 53.5%, sensitivity: 77.6%, specificity: 73.3%). Conclusions: elicits strong humoral however, about one quarter may need injection. had over 30% third injection. Funding Information: This work funded by Montpellier University Hospital, Muse I-SITE Program Grant, Montpellier. Declaration Interests: authors declare that there are conflict interests or personal relationships could have appeared influence reported this paper. Ethics Approval Statement: Subjects provided an informed consent approved Hospital institutional review board (IRB-MTP_2020_06_202000534 IRB-MTP _2021_04_202000534).
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ژورنال
عنوان ژورنال: Social Science Research Network
سال: 2021
ISSN: ['1556-5068']
DOI: https://doi.org/10.2139/ssrn.3886371